WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:negative regulation of peptidase activity       ID:GO:0010466
C=129; O=2; E=0.22; R=9.07; rawP=0.0203; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:biological process       Name:cellular nitrogen compound biosynthetic process       ID:GO:0044271
C=3746; O=2; E=6.40; R=0.31; rawP=1.0000; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
2  ENSG00000124920 NA C11orf9 chromosome 11 open reading frame 9 745 ENSG00000124920


Database:biological process       Name:transport       ID:GO:0006810
C=3338; O=5; E=5.70; R=0.88; rawP=1.0000; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132872 NA SYT4 synaptotagmin IV 6860 ENSG00000132872
2  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914
3  ENSG00000138821 NA SLC39A8 solute carrier family 39 (zinc transporter), member 8 64116 ENSG00000138821
4  ENSG00000074410 NA CA12 carbonic anhydrase XII 771 ENSG00000074410
5  ENSG00000135127 NA CCDC64 coiled-coil domain containing 64 92558 ENSG00000135127


Database:biological process       Name:tissue development       ID:GO:0009888
C=1449; O=3; E=2.48; R=1.21; rawP=0.4565; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000114638 NA UPK1B uroplakin 1B 7348 ENSG00000114638
2  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081
3  ENSG00000092295 NA TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) 7051 ENSG00000092295


Database:biological process       Name:RNA biosynthetic process       ID:GO:0032774
C=3306; O=2; E=5.65; R=0.35; rawP=1.0000; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
2  ENSG00000124920 NA C11orf9 chromosome 11 open reading frame 9 745 ENSG00000124920


Database:biological process       Name:negative regulation of catalytic activity       ID:GO:0043086
C=510; O=3; E=0.87; R=3.44; rawP=0.0549; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107
3  ENSG00000257017 NA HP haptoglobin 3240 ENSG00000257017


Database:biological process       Name:cell junction organization       ID:GO:0034330
C=195; O=2; E=0.33; R=6.00; rawP=0.0434; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081


Database:biological process       Name:ion transport       ID:GO:0006811
C=969; O=2; E=1.66; R=1.21; rawP=0.5002; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138821 NA SLC39A8 solute carrier family 39 (zinc transporter), member 8 64116 ENSG00000138821
2  ENSG00000074410 NA CA12 carbonic anhydrase XII 771 ENSG00000074410


Database:biological process       Name:single-organism metabolic process       ID:GO:0044710
C=9232; O=12; E=15.78; R=0.76; rawP=1.0000; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000161905 NA ALOX15 arachidonate 15-lipoxygenase 246 ENSG00000161905
3  ENSG00000243566 NA UPK3B uroplakin 3B 80761 ENSG00000243566
4  ENSG00000074410 NA CA12 carbonic anhydrase XII 771 ENSG00000074410
5  ENSG00000092295 NA TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) 7051 ENSG00000092295
6  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
7  ENSG00000105509 NA HAS1 hyaluronan synthase 1 3036 ENSG00000105509
8  ENSG00000124920 NA C11orf9 chromosome 11 open reading frame 9 745 ENSG00000124920
9  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
10  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914
11  ENSG00000128510 NA CPA4 carboxypeptidase A4 51200 ENSG00000128510
12  ENSG00000167757 NA KLK11 kallikrein-related peptidase 11 11012 ENSG00000167757


Database:biological process       Name:regulation of cellular metabolic process       ID:GO:0031323
C=4377; O=4; E=7.48; R=0.53; rawP=1.0000; adjP=1.0000
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
2  ENSG00000257017 NA HP haptoglobin 3240 ENSG00000257017
3  ENSG00000124920 NA C11orf9 chromosome 11 open reading frame 9 745 ENSG00000124920
4  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914


Database:molecular function       Name:serine-type endopeptidase inhibitor activity       ID:GO:0004867
C=95; O=2; E=0.15; R=13.41; rawP=0.0097; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:molecular function       Name:endopeptidase regulator activity       ID:GO:0061135
C=169; O=2; E=0.27; R=7.54; rawP=0.0286; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:molecular function       Name:structural constituent of cytoskeleton       ID:GO:0005200
C=76; O=2; E=0.12; R=16.76; rawP=0.0063; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171345 NA KRT19 keratin 19 3880 ENSG00000171345
2  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081


Database:molecular function       Name:structural molecule activity       ID:GO:0005198
C=621; O=4; E=0.98; R=4.10; rawP=0.0150; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000114638 NA UPK1B uroplakin 1B 7348 ENSG00000114638
3  ENSG00000171345 NA KRT19 keratin 19 3880 ENSG00000171345
4  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081


Database:molecular function       Name:endopeptidase inhibitor activity       ID:GO:0004866
C=165; O=2; E=0.26; R=7.72; rawP=0.0274; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:molecular function       Name:serine hydrolase activity       ID:GO:0017171
C=179; O=2; E=0.28; R=7.12; rawP=0.0318; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
2  ENSG00000167757 NA KLK11 kallikrein-related peptidase 11 11012 ENSG00000167757


Database:molecular function       Name:peptidase inhibitor activity       ID:GO:0030414
C=172; O=2; E=0.27; R=7.41; rawP=0.0295; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:molecular function       Name:serine-type endopeptidase activity       ID:GO:0004252
C=155; O=2; E=0.24; R=8.22; rawP=0.0244; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
2  ENSG00000167757 NA KLK11 kallikrein-related peptidase 11 11012 ENSG00000167757


Database:molecular function       Name:serine-type peptidase activity       ID:GO:0008236
C=177; O=2; E=0.28; R=7.20; rawP=0.0311; adjP=0.1060
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
2  ENSG00000167757 NA KLK11 kallikrein-related peptidase 11 11012 ENSG00000167757


Database:molecular function       Name:peptidase regulator activity       ID:GO:0061134
C=206; O=2; E=0.32; R=6.18; rawP=0.0411; adjP=0.1233
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107


Database:cellular component       Name:cell periphery       ID:GO:0071944
C=4377; O=12; E=6.42; R=1.87; rawP=0.0133; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000114638 NA UPK1B uroplakin 1B 7348 ENSG00000114638
3  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081
4  ENSG00000243566 NA UPK3B uroplakin 3B 80761 ENSG00000243566
5  ENSG00000138821 NA SLC39A8 solute carrier family 39 (zinc transporter), member 8 64116 ENSG00000138821
6  ENSG00000074410 NA CA12 carbonic anhydrase XII 771 ENSG00000074410
7  ENSG00000102854 NA MSLN mesothelin 10232 ENSG00000102854
8  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
9  ENSG00000105509 NA HAS1 hyaluronan synthase 1 3036 ENSG00000105509
10  ENSG00000171345 NA KRT19 keratin 19 3880 ENSG00000171345
11  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
12  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914


Database:cellular component       Name:cell-cell junction       ID:GO:0005911
C=288; O=3; E=0.42; R=7.11; rawP=0.0083; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000143375 NA CGN cingulin 57530 ENSG00000143375
3  ENSG00000092295 NA TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) 7051 ENSG00000092295


Database:cellular component       Name:extracellular region       ID:GO:0005576
C=2140; O=9; E=3.14; R=2.87; rawP=0.0023; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101443 NA WFDC2 WAP four-disulfide core domain 2 10406 ENSG00000101443
2  ENSG00000124107 NA SLPI secretory leukocyte peptidase inhibitor 6590 ENSG00000124107
3  ENSG00000257017 NA HP haptoglobin 3240 ENSG00000257017
4  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
5  ENSG00000128510 NA CPA4 carboxypeptidase A4 51200 ENSG00000128510
6  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914
7  ENSG00000116690 NA PRG4 proteoglycan 4 10216 ENSG00000116690
8  ENSG00000167757 NA KLK11 kallikrein-related peptidase 11 11012 ENSG00000167757
9  ENSG00000102854 NA MSLN mesothelin 10232 ENSG00000102854


Database:cellular component       Name:plasma membrane       ID:GO:0005886
C=4289; O=12; E=6.29; R=1.91; rawP=0.0112; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000114638 NA UPK1B uroplakin 1B 7348 ENSG00000114638
3  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081
4  ENSG00000243566 NA UPK3B uroplakin 3B 80761 ENSG00000243566
5  ENSG00000138821 NA SLC39A8 solute carrier family 39 (zinc transporter), member 8 64116 ENSG00000138821
6  ENSG00000074410 NA CA12 carbonic anhydrase XII 771 ENSG00000074410
7  ENSG00000102854 NA MSLN mesothelin 10232 ENSG00000102854
8  ENSG00000113645 NA WWC1 WW and C2 domain containing 1 23286 ENSG00000113645
9  ENSG00000105509 NA HAS1 hyaluronan synthase 1 3036 ENSG00000105509
10  ENSG00000171345 NA KRT19 keratin 19 3880 ENSG00000171345
11  ENSG00000243649 NA CFB complement factor B 629 ENSG00000243649
12  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914


Database:cellular component       Name:tight junction       ID:GO:0005923
C=97; O=2; E=0.14; R=14.06; rawP=0.0088; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000143375 NA CGN cingulin 57530 ENSG00000143375


Database:cellular component       Name:apical junction complex       ID:GO:0043296
C=113; O=2; E=0.17; R=12.07; rawP=0.0118; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000143375 NA CGN cingulin 57530 ENSG00000143375


Database:cellular component       Name:occluding junction       ID:GO:0070160
C=97; O=2; E=0.14; R=14.06; rawP=0.0088; adjP=0.0893
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000143375 NA CGN cingulin 57530 ENSG00000143375


Database:cellular component       Name:anchored to membrane       ID:GO:0031225
C=144; O=2; E=0.21; R=9.47; rawP=0.0187; adjP=0.1099
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000179914 NA ITLN1 intelectin 1 (galactofuranose binding) 55600 ENSG00000179914
2  ENSG00000102854 NA MSLN mesothelin 10232 ENSG00000102854


Database:cellular component       Name:cell junction       ID:GO:0030054
C=737; O=4; E=1.08; R=3.70; rawP=0.0212; adjP=0.1107
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163347 NA CLDN1 claudin 1 9076 ENSG00000163347
2  ENSG00000143375 NA CGN cingulin 57530 ENSG00000143375
3  ENSG00000132872 NA SYT4 synaptotagmin IV 6860 ENSG00000132872
4  ENSG00000092295 NA TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) 7051 ENSG00000092295


Database:cellular component       Name:intermediate filament       ID:GO:0005882
C=190; O=2; E=0.28; R=7.18; rawP=0.0313; adjP=0.1337
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171345 NA KRT19 keratin 19 3880 ENSG00000171345
2  ENSG00000186081 NA KRT5 keratin 5 3852 ENSG00000186081




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).